Tumour Agnostics pan-TRK

Assay VENTANA pan-TRK (EPR17341) Assay
Technical requirement OptiView on a VENTANA BenchMark instrument
pan-TRK kit insert
Status IVD
Interpretation The assay is designed to detect C-terminal protein expression, which allows for the detection of TRK-fusion as well as wild-type protein expression. The epitope detected by the antibody is encoded downstream of the tyrosine kinase domain within the 3 prime coding region of the neurotrophic tyrosine receptor kinase (NTRK) 1, 2 and 3 genes and is conserved across all three TRK proteins, A, B and C.

Staining: cytoplasmic, membranous and nuclear staining
Controls: appendix & cerebellum